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AOD-9604 Overview
AOD-9604 is a synthetic peptide fragment derived from the C-terminus of the somatotropin sequence (fragment 176–191, with an added N-terminal Tyr). It is studied for its effects on lipolytic and anti-lipogenic pathways, β3-adrenergic signaling, and downstream pathway dynamics in laboratory and preclinical models.
History
Developed in the late 1990s/early 2000s as a focused hGH fragment, AOD-9604 was advanced into early clinical programs to investigate mechanism-driven metabolic effects and safety. Subsequent summaries report randomized, placebo-controlled trials evaluating IGF-1, glucose tolerance, and immunogenicity endpoints in research settings.
AOD-9604 Structure
CAS #: 386264-39-7
Molecular Formula: C₇₈H₁₂₃N₂₃O₂₃S₂
Molecular Weight: 1815.1 g/mol
PubChem ID: 71300630
Research Findings
AOD-9604 has been studied in signaling, structural, and systemic models, with research exploring its effects on lipid pathway dynamics, substrate utilization, and remodeling processes. Studies also highlight its potential influence on cartilage modeling, skeletal signaling, and pathway activity in preclinical settings.
Key Areas of Research::
Signaling: Lipid pathways, substrate dynamics
Structural: Cartilage, skeletal, connective matrix
Systemic: Remodeling, viability, signaling
Together, these findings suggest experimental potential for AOD-9604 across signaling, structural, and systemic pathways. By modulating lipid pathway dynamics and supporting matrix integrity, AOD-9604 provides a versatile platform for research into substrate characterization, structural modeling, and systemic resilience in laboratory settings.
References
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